A study of bone marrow angiogenesis and its correlation with serum vascular endothelial growth factor levels in acute leukaemia
نویسندگان
چکیده
Background: Angiogenesis, which is the development of new capillaries from existing blood vessels, occurs in both developing embryo and postnatal life. The growth solid tumours requires micro vessels; therefore, tumour expansion correlates with extent angiogenesis.Methods: A prospective study was conducted on bone marrow trephine biopsies 40 cases acute leukaemia diagnosed complete count, aspiration examination, flow cytometry, including 20 control cases. Micro sections were stained immuno-histochemical stains using monoclonal antibodies to CD31, CD34 vWF. vessel density analysed at a 400× automated image analyser by two investigators independently. Data calculated, tabulated statistically statistical package for social sciences (SPSS) program version 18.Results: total 1522 vessels CD31 802 myeloid (AML), 512 lymphocytic leukemia (ALL) 208 group. microvessel (MVD) Von Willebrand factor (VWF) 70.83±20.76, 66.48±18.99 60.32±18.75 respectively while MVD lymphoblastic 62.74±21.09, 70.58±22.46 51.22±21.13 respectively. revealed significant difference between AML, ALL normal vWF antibody. Serum vascular endothelial (VEGF) concentration group 163.74±119.03, 168.23±154.22 43.45±9.14 respectively.Conclusions: Higher observed leukaemia. Present findings suggested potential significance characteristics as prognostic marker well its application improved selection patients anti-angiogenic other treatments.
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ژورنال
عنوان ژورنال: International Journal of Research in Medical Sciences
سال: 2022
ISSN: ['2320-6012', '2320-6071']
DOI: https://doi.org/10.18203/2320-6012.ijrms20223086